London Asthma Diagnostics Study Interview
Background
We’re inviting GPs and practice nurses to take part in a short qualitative interview as part of the London Asthma Diagnostics Study (ClinicalTrials.gov ID NCT06383130).
This study is evaluating whether a triple diagnostic approach — combining oscillometry with FeNO and spirometry with reversibility testing — can improve the diagnostic accuracy of adult asthma in real-world settings. Oscillometry is a quick, effort-independent lung function test that uses normal tidal breathing and may be more sensitive to small airways disease.
Chronic Venus Ulcer Study (allo-APZ2-CVU)
Background
Allo-APZ2-CVU is a vascular clinical trial investigating the efficacy and safety of allo-APZ2-CVU (a stem cell preparation) on wound healing of therapy-resistant, non-healing chronic venous ulcers (CVU). This is a novel treatment in a first-of-its-kind study for CVU, which are caused by venous insufficiency that severely impairs wound healing in the lower legs. It is a debilitating, painful condition with a high disease burden and infection rate. The standard treatment is compression dressings that help venous return, facilitating healing, but the results are variable, and many ulcers of this kind do not heal even with a good compression regimen.
It’s hoped that the results of this clinical trial will yield a new treatment that can be used for patients with CVU, improving healing potential in ulcers that won’t heal with compression alone; and reducing healing time in those that heal only very slowly.
LILAC Study
Background
LILAC-TIMI 76 is a randomized, double, blind placebo-controlled phase 3 trial investigating the efficacy and safety of the factor XI inhibitor abelacimab in~1,900 patients with AF deemed unsuitable for anticoagulation therapy. We are looking for participants who may be able to benefit from a trial of this revolutionary new medication.
OPTIMISE2 Study
Background
Optimise2 Study is a trial conducted by the University of Oxford which aims to deprescribe antihypertensive medication for adults that are 75 + who are prescribed with 2 or more antihypertensive medication. Patients who are prescribed with a lot of drugs are more likely to have reduced independence and higher likeliness of being admitted to the hospital due to side effects. These drugs reduces the risk of strokes and lowers blood pressures but in frail older adults, this may cause more harm than good such as causing kidney failures and fainting which can lead to serious falls.
Patients on this study will be doing follow up visits for 1 year after their 1:1 randomization to compare medical reduction and the usual care. The recruitment end date is 30-04-2027.
ECAL Study
Background
The ECAL trial, led by the University of Birmingham and Queen Mary University of London, is a large randomized study comparing electronic cigarettes (ECs) to combination nicotine replacement therapy (NRT) to help people with COPD quit smoking. Funded by the NIHR, it aims to recruit 1,250 smokers aged 35 and over, offering either an EC starter kit or 12 weeks of NRT alongside behavioral support. The main goal is to measure smoking abstinence at 12 months, with secondary outcomes including lung function, COPD symptoms, and quality of life. The study also explores the effects of switching to vaping on lung health and mental wellbeing.
CLOCS-2
Background
Cancer remains a leading cause of death globally, with early diagnosis crucial for effective treatment. CLOCS-2, a novel study, investigates the potential of everyday loyalty card data to identify early cancer signs. Focusing on various cancer types, CLOCS-2 compares purchasing patterns of participants to develop early detection methods. This innovative approach marks a promising stride in improving cancer outcomes.
BED & BN in primary care
Background
Binge Eating Disorder (BED) involves frequent episodes of consuming significantly large quantities of food, accompanied by a loss of control over eating behavior. These episodes are marked by eating a substantial amount of food within a discrete period, surpassing typical consumption, and a feeling of inability to control eating habits.
Bulimia nervosa (BN) is a severe and potentially life-threatening eating disorder marked by episodes of binge eating followed by compensatory actions, like self-induced vomiting, aimed at counteracting the consequences of overeating and preventing weight gain.
Re-appraising the use of Faecal calprotectin sample (FC)
Background
Faecal calprotectin (FC) serves as a recognized marker of inflammation, consistently displaying elevated levels in the stool of patients with inflammatory bowel disease (IBD) compared to control groups. Its utilization is endorsed by NICE for patients presenting with new-onset lower gastrointestinal symptoms. Through this research endeavor will contribute to refining referral pathways, especially concerning cases with borderline elevated results.
Measuring Loneliness study (INTERACT2)
Background
Social isolation and loneliness (SI&L) have well-documented public health implications, impacting both physical and mental well-being. To address the rising incidence of SI&L, particularly in the London Borough of Hammersmith & Fulham (LBHF &F), our research aims to assess its prevalence across England using online tools. We will focus on vulnerable populations, including those with limited cognitive capacity, developmental disorders, dementia, and serious mental illnesses, to identify interventions that can effectively tackle this issue. Our findings, disseminated through peer-reviewed journals, aim to inform policies and practices to address SI&L in communities across England.
Tricorder Study
Background
Tricorder represents a collaborative effort between The NHS North West London Integrated Care System, Betsi Cadwaladr University Health Board, and Imperial College London, aimed at advancing public health outcomes. The project seeks to evaluate the impact of equipping GPs with the Eko DUO device on early detection of heart failure (HF) among patients, as well as its potential cost-saving benefits for the NHS.
FluCamp
Background
FluCamp is a dedicated research organization with a primary focus on enhancing comprehension of viral illnesses, particularly respiratory infections such as the flu. Through meticulously conducted clinical trials involving volunteers under strict supervision, FluCamp aims to evaluate new treatments and propel medical research forward in this domain. By actively engaging volunteers, FluCamp endeavors to deepen our understanding of common viral infections and develop more effective treatments, ultimately striving to improve public health outcomes.
Active Brains
Background
Active Brains is a new website aimed at assisting older adults in maintaining brain and body health to prevent cognitive decline. Through promoting simple lifestyle changes such as increased activity, brain training games, and healthier eating, the platform aims to empower users. Ongoing research will assess the website’s effectiveness and cost-efficiency in delaying cognitive decline, providing valuable insights for improving support for older adults’ cognitive well-being.
There is accumulating evidence indicating that adopting healthy behaviors, particularly engaging in physical activity, and participating in cognitive exercises can enhance cognitive functioning and activities of daily living. A recent trial conducted in various settings has illustrated the potential effectiveness of integrating healthy behavior and cognitive interventions. This study aims to evaluate the efficacy of a website designed to promote cognitive health. Participants will be divided into two groups: older adults exhibiting signs of cognitive decline and those without any cognitive impairment. Within each group, individuals will be randomly assigned to one of three study arms: 1) standard care from their GP practice, 2) access to the Active Brains website, or 3) access to the Active Brains website with additional support from a trained individual via phone or email. The study will span five years, with cognitive skills assessments conducted at the end of the first year and again after five years. Additionally, dementia diagnoses will be tracked across the study groups over the five-year period.